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The major health concerns that are associated with tobacco, which are primarily cancer and cardiovascular disease... are not caused by nicotine per se, but instead they are caused by several other components of tobacco itself and tobacco
smoke.
Peter Attia
Unlike Synthetic Forms, Tobacco-Derived Nicotine May Contain Carcinogens
AMA #70: Nicotine: impact on cognitive function, performance, and mood, health risks, delivery modalities, and smoking cessation strategies
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