and I wouldn't be talking about ssris if they didn't, in fact work. Yes, there are many problems with ssris. They do carry certain side effects. In many individuals also about a third of people that take ssris, don't derive any benefit. It doesn't relieve their symptoms of depression. However, for the other two-thirds, there's often a relief of some, if not all of the symptoms of major depression. The problem is the side effects that accompany those ssris. And so these days, ssris are a complicated topic. It's sort of what I would call a barbed wire topic because We often hear about all the problems with them, but these drugs also have saved a lot of lives. They've also improved a lot of lives. The issue is that they tend to have varying effects on different individuals and sometimes varying effects over time. So, the work for a while, then they won't work for while